Bias in Peer Review Contributing to Unfounded Reintroduction of PGS into IVF, Warn CHR Investigators in Latest OPINIONs Commentary

Bias in Peer Review Contributing to Unfounded Reintroduction of PGS into IVF, Warn CHR Investigators in Latest OPINIONs Commentary

Posted: Updated:
The Center of Human Reproduction, a world-leading New York fertility center, calls for a more unbiased discussion of preimplantation genetic screening (PGS) in infertility care.

This article was originally distributed via 24-7 Press Release Newswire. 24-7 Press Release Newswire, WorldNow and this Site make no warranties or representations in connection therewith.

NEW YORK, NY, June 23, 2014 /24-7PressRelease/ -- In the latest piece in OPINIONs, an online commentary series, the Center for Human Reproduction (CHR) warns against the premature reintroduction of preimplantation genetic screening (PGS) into routine infertility care. Inherent biases in peer review, CHR points out, contribute to the reintroduction.

PGS is a method of embryo selection, used in association with in vitro fertilization (IVF), that aims to remove genetically abnormal embryos before embryo transfer into the uterus, thereby, theoretically, increasing chances of IVF success. The procedure first gained popularity approximately 10 years ago, and was widely used before it was demonstrated to have the potential of actually reducing pregnancy chances, especially in older women.

CHR was then the first center to warn against the procedure's potential to cause harm but the warnings went unheeded. Eventually, research by European investigators gained attention, and PGS fell into relative disrepute, with professional organizations formally releasing statements about its ineffectiveness.

Despite lack of any evidence that recently introduced, technologically superior PGS can improve IVF pregnancy chances, the new form of PGS is gaining popularity once again. CHR, however, cautions that claims about efficacy of this new PGS, found in even prestigious peer-reviewed medical journals, are based on inappropriate study designs and incorrect statistical data analyses. Moreover, none of these publications so far established a specific patient population in which use of PGS may, indeed, be beneficial.

Acceptance of misleading articles by peer-reviewed medical journals is, likely, the result of a typical shortcoming of the peer review process. Reviewers selected by editors are usually experts in the area of science where they are asked to review manuscripts. Experts on PGS are, however, mostly intellectually invested in the theoretically very attractive concept of PGS, or have financial ties to laboratories that perform PGS. Their conscious or unconscious biases, therefore not surprisingly, contribute to acceptance of manuscripts with serious shortcomings, and exclusion of manuscripts with opposing viewpoints. CHR calls for a more unbiased discussion of advantages and disadvantages of PGS in the medical literature.

The full-length commentary on the subject can be found on CHR's website.

About the Center for Human Reproduction
The Center for Human Reproduction (CHR), located in New York City, is one of the world's leading clinical and research centers in reproductive medicine and infertility. Always vocal on issues impacting fertility patients, CHR has become a prominent opinion leader in the field, repeatedly initiating important discussions, leading to changes in practice patterns.

Information contained on this page is provided by an independent third-party content provider. WorldNow and this Station make no warranties or representations in connection therewith. If you have any questions or comments about this page please contact pressreleases@worldnow.com.



For the original version on 24-7 Press Release Newswire visit: http://www.24-7pressrelease.com/press-release/bias-in-peer-review-contributing-to-unfounded-reintroduction-of-pgs-into-ivf-warn-chr-investigators-in-latest-opinions-commentary-388466.php

  • Most Popular StoriesMost Popular StoriesMore>>

  • Father beats accused child abuser, Daytona police say

    Father beats accused child abuser, Daytona police say

    Police say a Daytona Beach father beat an 18-year-old man unconscious after finding him sexually abusing his son. Authorities say the father called 911 early Friday after he walked in on the alleged abuse.Frolander motionless on the living room floor. He had several knots on his face and was bleeding from the mouth. Police said the father -- who was not identified -- told investigators he walked in as Frolander was abusing the boy. Police did not release the boy's age, but Frolander is charge...More >>
    Police say a Daytona Beach father beat an 18-year-old man unconscious after finding him sexually abusing his son. Authorities say the father called 911 early Friday after he walked in on the alleged abuse.Frolander motionless on the living room floor. He had several knots on his face and was bleeding from the mouth. Police said the father -- who was not identified -- told investigators he walked in as Frolander was abusing the boy. Police did not release the boy's age, but Frolander is charge...More >>
  • Coming soon...Wal-Mart

    Coming soon...Wal-Mart

    On Wednesday the Yuma City Council voted to change the zoning designation on the proposed land acquired by Wal-Mart. The property located near the intersection of Avenue B and 8th Street was the home of a mobile home park as zones for residential use; the new designation changes that to mixed which will allow the new store to move in to the property. The new store will be the fifth Wal-Mart for Yuma County.More >>
    On Wednesday the Yuma City Council voted to change the zoning designation on the proposed land acquired by Wal-Mart. The property located near the intersection of Avenue B and 8th Street was the home of a mobile home park as zones for residential use; the new designation changes that to mixed which will allow the new store to move in to the property. The new store will be the fifth Wal-Mart for Yuma County.More >>
  • Mercury rising

    Mercury rising

    Living in the southwest, warm temps are just part of life; but, lately as the mercury begins to rise it has proven to be too much for some. Emergency crews have been called out fordehydrations calls and area utilities have recorded larger than normal power uses. Some companies have opened their doors offering passer by’s a cool zone and even the Salvation Army has scoured the city looking for people in aide to help them get hydrated and get some shelter from the sun.More >>
    Living in the southwest, warm temps are just part of life; but, lately as the mercury begins to rise it has proven to be too much for some. Emergency crews have been called out fordehydrations calls and area utilities have recorded larger than normal power uses. Some companies have opened their doors offering passer by’s a cool zone and even the Salvation Army has scoured the city looking for people in aide to help them get hydrated and get some shelter from the sun.More >>
  • Man wanted in US arrested in Mexicali

    Man wanted in US arrested in Mexicali

    MEXICALI, MX - A man wanted by authorities in Santa Maria, California was arrested in the Desert Southwest. Mexicali Police have arrested Severiano Leon Flores.More >>
  • Crime Watch

    Police investigating dead body found in parked car

    Police investigating dead body found in parked car

    YUMA, Ariz. (13 On Your Side) - Yuma police say a dead woman was found in a car parked at Food City on 8th Street on Tuesday night, at around 6:20 p.m. Police are investigating her cause of death andMore >>
    Yuma police are investigating the death of a woman who was found in a parked car Tuesday night.More >>
  • Reporter

    Grecia Aguilar

    Grecia Aguilar

    Grecia Aguilar joined "13 On Your Side" as the Bureau Chief Reporter assigned to El Centro. She graduated from San Diego State University in 2011 with a degree in Journalism and Spanish. During her seniorMore >>
    Grecia Aguilar joined "13 On Your Side" as the Bureau Chief Reporter assigned to El Centro. She graduated from San Diego State University in 2011 with a degree in Journalism and Spanish.More >>
  • Yuma

    Transit director responds to bus rider concerns

    Transit director responds to bus rider concerns

    YUMA, AZ (13 On Your Side) - Yesterday, 13 On Your Side spoke with 72-year-old Robert Perez, who uses public transportation and isn't happy with the service he's getting. He says, "you have to wait inMore >>
    Yesterday, 13 On Your Side spoke with 72-year-old Robert Perez, who uses public transportation and isn't happy with the service he's getting.More >>
  • Yuma

    Navy officially names fleet ship after Yuma

    Navy officially names fleet ship after Yuma

    Pretty soon a ship will be traveling the world bearing Yuma's name.More >>
    Pretty soon a ship will be traveling the world bearing Yuma's name.More >>